Disease-gene associations mined from literature

Literature associating TAB2 and frontometaphyseal dysplasia

TAB2 [ENSP00000356426]

Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development; Zinc fingers RANBP2-type

Synonyms:  TAB2,  TAB2p,  hTAB2,  Q9NYJ8,  TAB2-001 ...

Linkouts:  STRING  Pharos  UniProt