DISEASES

Disease-gene associations mined from literature

Literature associating UBE2T and Fanconi anemia complementation group L

UBE2T [ENSP00000356243]

Cell proliferation-inducing gene 50 protein; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys- 63'-linked polyubiquitination.

Synonyms:  UBE2T,  UBE2Tp,  hUBE2T,  A0A024R9A9,  Q9NPD8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM