DISEASES

Disease-gene associations mined from literature

Literature associating KDM5B and ascending colon cancer

KDM5B [ENSP00000356234]

Retinoblastoma-binding protein 2 homolog 1; Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity); AT-rich interaction domain containing

Synonyms:  KDM5B,  KDM5Bp,  hKDM5B,  B3KMS2,  B3KMS8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM