DISEASES

Disease-gene associations mined from literature

Literature associating RGS17 and jejunal somatostatinoma

RGS17 [ENSP00000356194]

Regulator of G-protein signaling 17; Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).

Synonyms:  RGS17,  RGS17p,  hRGS17,  Q9UGC6,  RGS17-001 ...

Linkouts:  STRING  Pharos  UniProt