DISEASES

Disease-gene associations mined from literature

Literature associating CD55 and Plasmodium falciparum malaria

CD55 [ENSP00000356030]

CD55 molecule, decay accelerating factor for complement (Cromer blood group); This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage; Blood group antigens

Synonyms:  CD55,  CD55p,  hCD55,  B1AP13,  B1AP15 ...

Linkouts:  STRING  Pharos  UniProt