Literature associating CR1 and malaria
CR1 [ENSP00000356016]
Complement receptor type 1; Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages . Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation . Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d . Plays also a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells . ECO:0000269|PubMed:2963069, ECO:0000269|PubMed:2972794,
Synonyms: CR1p, hCR1, E9PDY4, E9PQN4, H0YE06 ...