DISEASES

Disease-gene associations mined from literature

Literature associating IRF6 and ankyloblepharon-ectodermal defects-cleft lip/palate syndrome

IRF6 [ENSP00000355988]

Interferon regulatory factor 6; Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity); Belongs to the IRF family.

Synonyms:  IRF6,  IRF6p,  hIRF6,  B1AJU4,  G0Z349 ...

Linkouts:  STRING  Pharos  UniProt  OMIM