Literature associating FLVCR1 and proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome
Feline leukemia virus subgroup C receptor-related protein 1; Isoform 1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies. Causes susceptibility to FeLV-C in vitro; Solute carriers
Synonyms: FLVCR1, FLVCR1p, hFLVCR1, Q9Y5Y0, FLVCR ...