DISEASES

Disease-gene associations mined from literature

Literature associating DACT2 and glioblastoma proneural subtype

DACT2 [ENSP00000355760]

Dishevelled-binding antagonist of beta-catenin 2; Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling (By similarity); Belongs to the dapper family.

Synonyms:  DACT2,  DACT2p,  hDACT2,  Q5SW24,  C6orf116 ...

Linkouts:  STRING  Pharos  UniProt  OMIM