DISEASES

Disease-gene associations mined from literature

Literature associating CD47 and hereditary spherocytosis

CD47 [ENSP00000355361]

Antigenic surface determinant protein OA3; Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection; CD molecules

Synonyms:  CD47,  CD47p,  hCD47,  Q08722,  MER6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM