DISEASES

Disease-gene associations mined from literature

Literature associating INO80 and Floating-Harbor syndrome

INO80 [ENSP00000355205]

Putative DNA helicase INO80 complex homolog 1; DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle.

Synonyms:  INO80p,  hINO80,  A0A024R9R7,  H0YMN5,  INOC1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM