Disease-gene associations mined from literature

Literature associating GRM1 and proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome

GRM1 [ENSP00000354896]

Glutamate receptor, metabotropic 1; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.

Synonyms:  GRM1,  GRM1p,  hGRM1,  Q13255,  GPRC1A ...

Linkouts:  STRING  Pharos  UniProt