DISEASES

Disease-gene associations mined from literature

Literature associating MAGEC2 and malignant anus melanoma

MAGEC2 [ENSP00000354660]

Hepatocellular carcinoma-associated antigen 587; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex; MAGE family

Synonyms:  MAGEC2,  MAGEC2p,  hMAGEC2,  MAGEC2-001,  Q9UBF1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM