Literature associating MAGEC2 and malignant anus melanoma
Hepatocellular carcinoma-associated antigen 587; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex; MAGE family
Synonyms: MAGEC2, MAGEC2p, hMAGEC2, MAGEC2-001, Q9UBF1 ...