DISEASES

Disease-gene associations mined from literature

Literature associating PTGS1 and chronic cystitis

PTGS1 [ENSP00000354612]

Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells; Belongs to the prostaglandin G/H synthase family.

Synonyms:  PTGS1,  PTGS1p,  hPTGS1,  P23219,  PTGS1-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM