DISEASES

Disease-gene associations mined from literature

Literature associating ZEB1 and esophageal cancer

ZEB1 [ENSP00000354487]

Zinc finger E-box binding homeobox 1; Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs; ZF class homeoboxes and pseudogenes

Synonyms:  ZEB1,  LOC100996668,  ZEB1p,  hZEB1,  F6TDF5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM