Disease-gene associations mined from literature

Literature associating MATR3 and amyotrophic lateral sclerosis type 19

MATR3 [ENSP00000354346]

Matrin 3; May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. May bind to specific miRNA hairpins.

Synonyms:  MATR3,  MATR3p,  hMATR3,  SNHG4,  A8MXP9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM