DISEASES

Disease-gene associations mined from literature

Literature associating TLR9 and parasitic protozoa infectious disease

TLR9 [ENSP00000353874]

Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production.

Synonyms:  TLR9,  TLR9p,  hTLR9,  C3W5P5,  Q9NR96 ...

Linkouts:  STRING  Pharos  UniProt