Disease-gene associations mined from literature

Literature associating TLR9 and malaria

TLR9 [ENSP00000353874]

Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response . Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production . ECO:0000269|PubMed:11564765, ECO:0000269|PubMed:17932028,

Synonyms:  TLR9,  TLR9p,  hTLR9,  Q9NR96,  Q9NR96p ...

Linkouts:  STRING  Pharos  UniProt