Disease-gene associations mined from literature

Literature associating CUX1 and myeloid and lymphoid neoplasms associated with FGFR1 abnormalities

CUX1 [ENSP00000353401]

Homeobox protein cut-like 1; Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator (By similarity); CUT class homeoboxes and pseudogenes

Synonyms:  CUX1,  CUX1p,  hCUX1,  CUTL1,  P39880 ...

Linkouts:  STRING  Pharos  UniProt