Disease-gene associations mined from literature

Literature associating TEAD4 and atypical teratoid rhabdoid tumor

TEAD4 [ENSP00000352926]

Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif; TEA domain transcription factors

Synonyms:  TEAD4,  TEAD4p,  hTEAD4,  D3DUQ6,  H0Y7B0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM