Literature associating PTPN22 and autoimmune thyroiditis
PTPN22 [ENSP00000352833]
Tyrosine-protein phosphatase non-receptor type 22; Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules . Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue . Dephosphorylates ZAP70 at its activating 'Tyr-493' residue . Dephosphorylates the immune system activator SKAP2 . Positively regulates toll-like receptor (TLR)-induced type 1 interferon production . Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy . ECO:0000269|PubMed:18056643, ECO:0000269|PubMed:19167335, ECO:0000269|PubMed:21719704, ECO:0000269|PubMed:23871208,; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 4 subfamily.
Synonyms: PTPN22, PTPN22p, hPTPN22, A0A0A0MTD9, A0A0A0MTE6 ...