Literature associating PTPN22 and type 1 diabetes mellitus 8
Protein tyrosine phosphatase, non-receptor type 22 (lymphoid); Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr- 493' residue. Dephosphorylates the immune system activator SKAP2. Positively regulates toll-like receptor (TLR)-induced type 1 interferon production. Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro- inflammatory cytokine secretion and autophagy; Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.
Synonyms: PTPN22, PTPN22p, hPTPN22, E9PM87, E9PMK2 ...