DISEASES

Disease-gene associations mined from literature

Literature associating HIST1H2AI and syndromic X-linked intellectual disability

HIST1H2AI [ENSP00000351589]

Histone cluster 1, H2ai; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Synonyms:  HIST1H2AI,  HIST1H2AG,  HIST1H2AH,  HIST1H2AK,  HIST1H2AL ...

Linkouts:  STRING  Pharos  UniProt