DISEASES

Disease-gene associations mined from literature

Literature associating MAX and renal oncocytoma

MAX [ENSP00000351490]

Class D basic helix-loop-helix protein 4; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements.

Synonyms:  MAX,  A0A024R682,  G3V2N4,  G3V2R5,  G3V302 ...

Linkouts:  STRING  Pharos  UniProt  OMIM