DISEASES

Disease-gene associations mined from literature

Literature associating WDR5 and Kabuki syndrome

WDR5 [ENSP00000351446]

BMP2-induced 3-kb gene protein; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation; Belongs to the WD repeat WDR5/wds family.

Synonyms:  WDR5,  WDR5p,  hWDR5,  P61964,  V9GYQ5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM