Literature associating ZC3HC1 and hereditary desmoid disease
Nuclear-interacting partner of anaplastic lymphoma kinase; Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events; Zinc fingers
Synonyms: ZC3HC1, ZC3HC1p, hZC3HC1, C9J0I9, C9J672 ...