Disease-gene associations mined from literature

Literature associating EPHB4 and liver carcinoma in situ

EPHB4 [ENSP00000350896]

Ephrin type-B receptor 4; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells.

Synonyms:  EPHB4,  EPHB4p,  hEPHB4,  P54760,  Q541P7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM