Literature associating ARPIN and autosomal dominant Emery-Dreifuss muscular dystrophy 4
Actin-related protein 2/3 complex inhibitor; Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence; Belongs to the Arpin family.
Synonyms: ARPIN, H0YMP5, Q7Z6K5, C15orf38, H0YMP5p ...