DISEASES

Disease-gene associations mined from literature

Literature associating ITGAL and diffuse infiltrative lymphocytosis syndrome

ITGAL [ENSP00000349252]

Leukocyte function-associated molecule 1 alpha chain; Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha-L/beta-2 is also a receptor for F11R. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.

Synonyms:  ITGAL,  B4DQ77,  B4E021,  H3BNL5,  H3BS37 ...

Linkouts:  STRING  Pharos  UniProt  OMIM