DISEASES

Disease-gene associations mined from literature

Literature associating UBE2C and methotrexate-associated lymphoproliferation

UBE2C [ENSP00000348838]

(E3-independent) E2 ubiquitin-conjugating enzyme C; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit; Ubiquitin conjugating enzymes E2

Synonyms:  UBE2C,  UBE2Cp,  hUBE2C,  K4DI81,  O00762 ...

Linkouts:  STRING  Pharos  UniProt  OMIM