Literature associating TRIM13 and autonomic nervous system neoplasm
B-cell chronic lymphocytic leukemia tumor suppressor Leu5; E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor; Belongs to the TRIM/RBCC family.
Synonyms: TRIM13, TRIM13p, hTRIM13, A0A024RDU3, O60858 ...