DISEASES

Disease-gene associations mined from literature

Literature associating TRIM13 and autonomic nervous system neoplasm

TRIM13 [ENSP00000348299]

B-cell chronic lymphocytic leukemia tumor suppressor Leu5; E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor; Belongs to the TRIM/RBCC family.

Synonyms:  TRIM13,  TRIM13p,  hTRIM13,  A0A024RDU3,  O60858 ...

Linkouts:  STRING  Pharos  UniProt