Disease-gene associations mined from literature

Literature associating SREBF1 and fatty liver disease

SREBF1 [ENSP00000348069]

Sterol regulatory element binding transcription factor 1; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'); Basic helix-loop-helix proteins

Synonyms:  SREBF1,  SREBF1p,  hSREBF1,  B5MD58,  F6V242 ...

Linkouts:  STRING  Pharos  UniProt  OMIM