DISEASES

Disease-gene associations mined from literature

Literature associating FAS and panniculitis

FAS [ENSP00000347979]

Tumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro); CD molecules

Synonyms:  CD95,  E6Y7C3,  E6Y7C4,  FAS-001,  FAS-002 ...

Linkouts:  STRING  Pharos  UniProt  OMIM