Disease-gene associations mined from literature

Literature associating WARS and early infantile epileptic encephalopathy 29

WARS [ENSP00000347495]

Tryptophan--tRNA ligase, cytoplasmic; Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression; Belongs to the class-I aminoacyl-tRNA synthetase family.

Synonyms:  WARS,  A0A024R6K8,  B4DTK8,  G3V227,  G3V277 ...

Linkouts:  STRING  Pharos  UniProt  OMIM