Disease-gene associations mined from literature

Literature associating NKX2-1 and carotid body cancer

NKX2-1 [ENSP00000346879]

Homeobox protein Nkx-2.1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity); Belongs to the NK-2 homeobox family.

Synonyms:  NKX2-1,  F8VVG2,  P43699,  F8VVG2p,  hF8VVG2 ...

Linkouts:  STRING  Pharos  UniProt