Literature associating NKX2-1 and malignant mesothelioma
Thyroid-specific enhancer-binding protein; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity); Belongs to the NK-2 homeobox family.
Synonyms: NKX2-1, F8VVG2, P43699, Q13306, TTF-1 ...