DISEASES

Disease-gene associations mined from literature

Literature associating SPAM1 and cystitis cystica

SPAM1 [ENSP00000345849]

Sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding); Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid; Belongs to the glycosyl hydrolase 56 family.

Synonyms:  SPAM1,  SPAM1p,  hSPAM1,  C9J2X5,  P38567 ...

Linkouts:  STRING  Pharos  UniProt  OMIM