DISEASES

Disease-gene associations mined from literature

Literature associating MAFK and fibrosarcoma

MAFK [ENSP00000344903]

V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor; Belongs to the bZIP family. Maf subfamily.

Synonyms:  MAFK,  A0A024R804,  A8WFP5,  O60675,  A8WFP5p ...

Linkouts:  STRING  Pharos  UniProt  OMIM