DISEASES

Disease-gene associations mined from literature

Literature associating TRIM14 and bone carcinoma

TRIM14 [ENSP00000344208]

Tripartite motif-containing protein 14; Plays a role in the innate immune defense against viruses. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF- kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. Positively regulates the cGAS-induced type I interferon signaling pathway by stabilizing cGAS/MB21D1 and inhibiting its autophagic degradation; Belongs to the TRIM/RBCC family.

Synonyms:  TRIM14,  TRIM14p,  hTRIM14,  A0A024R165,  F2Z2M2 ...

Linkouts:  STRING  Pharos  UniProt