Literature associating IFNAR2 and Aicardi-Goutieres syndrome
Interferon (alpha, beta and omega) receptor 2; Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity.
Synonyms: IFNAR2, IFNAR2p, hIFNAR2, C9JCU0, C9JM33 ...