Disease-gene associations mined from literature

Literature associating ESR2 and sporadic breast cancer

ESR2 [ENSP00000343925]

Nuclear receptor subfamily 3 group A member 2; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.

Synonyms:  ESR2,  ESR2p,  hESR2,  F1D8N3,  G3V5M5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM