DISEASES

Disease-gene associations mined from literature

Literature associating SP100 and telogen effluvium

SP100 [ENSP00000343023]

Nuclear dot-associated Sp100 protein; Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53- mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation; Bromodomain containing

Synonyms:  SP100,  SP100p,  hSP100,  C9JBL0,  E9PHV6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM