DISEASES

Disease-gene associations mined from literature

Literature associating NCR3 and chronic intestinal vascular insufficiency

NCR3 [ENSP00000342156]

Natural cytotoxicity triggering receptor 3; Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation; CD molecules

Synonyms:  NCR3,  NCR3p,  hNCR3,  1C7,  LY117 ...

Linkouts:  STRING  Pharos