DISEASES

Disease-gene associations mined from literature

Literature associating SLPI and bone disease

SLPI [ENSP00000342082]

WAP four-disulfide core domain protein 4; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells; WAP four-disulfide core domain containing

Synonyms:  SLPI,  P03973,  Q6LDI0,  P03973p,  hP03973 ...

Linkouts:  STRING  Pharos  UniProt  OMIM