DISEASES

Disease-gene associations mined from literature

Literature associating PTN and common peroneal nerve lesion

PTN [ENSP00000341170]

Heparin-binding neurite outgrowth-promoting factor 1; Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. Binds to cell-surface target proteins via their chondroitin sulfate groups. Down-regulates PTPRZ1 activity; Belongs to the pleiotrophin family.

Synonyms:  PTN,  A0A024R778,  C9JR52,  P21246,  PTN-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM