Literature associating PTN and nasal cavity olfactory neuroblastoma
Heparin-binding neurite outgrowth-promoting factor 1; Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. Binds to cell-surface target proteins via their chondroitin sulfate groups. Down-regulates PTPRZ1 activity; Belongs to the pleiotrophin family.
Synonyms: PTN, A0A024R778, C9JR52, P21246, PTN-001 ...