DISEASES

Disease-gene associations mined from literature

Literature associating CRHR2 and intrahepatic cholestasis of pregnancy

CRHR2 [ENSP00000340943]

Corticotropin releasing hormone receptor 2; G-protein coupled receptor for CRH (corticotropin- releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.

Synonyms:  CRHR2,  CRHR2p,  hCRHR2,  C9JZM9,  CRHR2-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM