Literature associating CRHR2 and intrahepatic cholestasis of pregnancy
Corticotropin releasing hormone receptor 2; G-protein coupled receptor for CRH (corticotropin- releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
Synonyms: CRHR2, CRHR2p, hCRHR2, C9JZM9, CRHR2-001 ...