Literature associating PAX4 and type 2 diabetes mellitus
Paired box protein Pax-4; Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity; PRD class homeoboxes and pseudogenes
Synonyms: PAX4, PAX4p, hPAX4, G3V4Q1, J3KPG0 ...