DISEASES

Disease-gene associations mined from literature

Literature associating TRIM2 and Charcot-Marie-Tooth disease axonal type 2T

TRIM2 [ENSP00000339659]

RING-type E3 ubiquitin transferase TRIM2; UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance; Belongs to the TRIM/RBCC family.

Synonyms:  TRIM2,  TRIM2p,  hTRIM2,  C9J084,  C9JVI3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM