Disease-gene associations mined from literature

Literature associating SPTY2D1 and autoimmune glomerulonephritis

SPTY2D1 [ENSP00000337991]

SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae); Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro). Facilitates formation of tetrameric histone complexes containing histone H3 and H4. Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA; Belongs to the SPT2 family.

Synonyms:  SPTY2D1,  SPTY2D1p,  hSPTY2D1,  B4E223,  Q68D10 ...

Linkouts:  STRING  Pharos  UniProt